At the start of the game, each player holds three cards and on a turn a player draws one card, then plays one card. By playing cards, you can put new rules into play that change numerous aspects of the game: how many cards to draw or play, how many cards you can hold in hand or keep on the table in front of you, and (most importantly) how to win the game.

Anatomy Fluxx takes players deep into the human body, and from Blood Vessels , Bones , Testes , and Uterus , the game is packed with body bits that keep you ticking. Be on the lookout for Virus , Mutation , and Bacteria Creepers; and UnGoals like Cancer . The game also includes two learning rules to get your brain in gear with anatomical trivia. Anatomy Fluxx is for external use only.